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Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder in addition to being an aid to stopping smoking treatment.'Obesity is still a major public health concern,' said Jean-Marc Guettier, M.D., director in the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination using a healthy lifestyle that features a reduced-calorie exercise and dieting, Contrave provides another treatment option for chronic weight management for people who are obese or are overweight and possess at least one weight-related health.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for starters year. All patients received lifestyle modification that contained a reduced- calorie diet and regular exercise. Results from a medical trial that enrolled patients without diabetes demonstrated that patients had the average weight loss of 4.1% as opposed to participants who were given placebos) during a 12- month period, while another study involving patients with diabetes type 2 symptoms had a typical weight loss of 2% over treatment with placebo at 12 months. Using two separate drugs to shed pounds can be very effective you will find combinations as you're watching FDA now awaiting approval. When dealing with weight reduction and the those who go through it you ought to err assisting caution and let the FDA do its job and demand some research be done so the public is aware of the side effects and hazards of the medications before we take them. Keep in mind that drug companies have been in business to make money and that they would say anything to keep people on their own medications. Researchers found that participants using this drug for a year, dropped a few pounds within a month and have kept the body weight off through the 56 weeks from the study. Contrave is really a combination with the drugs naltrexone and bupropion, which generally seems to reflect a new trend of weight-loss drugs which can be made up of more than one active ingredient, which may make them more efficient and safer. Combo-pilling could be the newest fad or better yet the newest into the future under scrutiny and therefore it is just more publicly known although in the past, comb-pilling for losing weight has been around since the eighties. The biggest reason that using a combination of pills has become popular is the fact that since right now there aren't long term prescription weight loss supplements that have been licensed by the FDA besides orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications although some people might of the combinations are actually rejected or have yet to be approved by the FDA. Seizures certainly are a side effect with Contrave and shouldn't be taken in people with seizure disorders. The drug may also raise blood pressure and heartbeat, and mustn't be used in people who have a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise blood pressure level and heart rate and must not used in patients with uncontrolled high blood pressure level, as well as by you aren't heart-related and cerebrovascular (circulation system dysfunction impacting your brain) disease. Patients using a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes which has a boxed warning to alert physicians and patients for the increased chance of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stopping smoking. Approving a drug with this many potentially lethal unwanted side effects is inconsistent with all the mission statement from the FDA. The power from the drug manufacturing lobby is blatantly evident within the approval of several drugs requiring 'post-marketing' studies which might be clearly significant to overall drug safety within the US.