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Combo-pilling will be the newest fad or also the newest into the future under scrutiny and for that reason it is just more publicly known lately, comb-pilling for weight loss has been around since the eighties. The biggest reason that using a combination of pills has become popular is the fact that as of right now there are no long term prescription weight loss supplements that have been licensed by the FDA other than orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations are actually rejected or have yet to be licensed by the FDA. Seizures are a side effect with Contrave and shouldn't be taken in individuals with seizure disorders. The drug also can raise blood pressure and pulse rate, and mustn't be used in individuals with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with the drug. 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